Suppository Drugs

Definition
A suppository is a solid dosage form that is inserted into the rectum (rectal suppository), vagina (vaginal suppository), or urethra (urethral suppository), where it dissolves or melts and exerts local or systemic effects. Suppositories are used to deliver both systemically and locally acting medications.
They are of three major types
Rectal Suppository,  which is inserted into the Anus
Vaginal Suppository and Urethral Suppository used in the treatment of erectile dysfunction. Urethral Suppository are however rare

Composition
Several different ingredients can be used to form the base of a suppository: cocoa butter or a similar substitute, polyethylene glycol, hydrogels, and glycerinated gelatin. The type of material used depends on the type of suppository, the type of drug, and the conditions in which the suppository will be stored.
What it treats
This medication is used to treat hemorrhoids and itching/swelling in the rectum and anus. It is also used with other medications to treat certain intestinal problems (such as ulcerative colitis of the rectum and other rectal/anal inflammatory conditions).

Example includes:
• Valium (Diazepam) ...
• Muse (Alprostadil) ...
• Phenergan (Promethazine) ...
• Opana (Oxymorphone) & Morphine.
• Anusol etc
Rectal suppositories go in your bottom. They are about an inch long and have a rounded or bullet-shaped tip. You might take them to treat:
• Allergies
• Anxiety
• Asthma
• Constipation
• Fever
• Hemorrhoids
• Motion sickness
• Nausea
• Pain and itching
• Mental health problems, such as schizophrenia or bipolar disorder
Vaginal suppositories are oval-shaped. You can use them for:
• Bacterial or fungal infections
• Vaginal dryness
• Birth control
Why Use Them
You might need a suppository if:
• The drug you’re taking would break down too quickly in your digestive tract if you took it as a pill or liquid.
• You can’t swallow medicine.
• You’re vomiting and can't keep a pill or liquid down.
• The medicine tastes too bad to take by mouth.
How to Insert Them
To put in a rectal suppository:
• Go to the bathroom first to try to empty your colon.
• Wash your hands with soap and warm water.
• Unwrap the suppository.
• Rub a water-based lubricant over the tip or dip it in water. It will help you slide it in smoothly.
• Get in a comfortable position. You can stand with one leg up on a chair or lie on your side with one leg straight and the other bent in toward your stomach.
• Gently spread your buttocks open.
• Carefully push the suppository, tapered end first, about 1 inch into your bottom.
• Close your legs and sit or lie still for about 15 minutes to let it dissolve.
• Wash your hands again with warm water and soap.
To put a suppository into your vagina:
• Wash your hands with soap and warm water.
• Unwrap the suppository and put it into the applicator.
• Lie on your back with your knees bent toward your chest, or stand with your knees bent and your feet a few inches apart.
• Gently put the applicator into your vagina as far is it will go without feeling uncomfortable.
• Press on the plunger at the end of the applicator to push the suppository in, then remove the applicator.
• Lie down for a few minutes to let the medicine absorb.
• Wash your hands again with soap and warm water.
Vaginal suppositories can be messy, so you may want to wear a pad for a little while after you put one in.
To put in a urethral suppository:
• Go to the bathroom to empty your bladder.
• Remove the cover from the applicator.
• Stretch your penis to its full length to open the urethra, and put the applicator into the hole at the tip.
• Gently push the button at the top of the applicator until it stops. Hold it there for 5 seconds.
• Sway the applicator from side to side to make sure the suppository has gone in.
• Pull out the applicator. Make sure there’s no more medicine in it.
• While your penis is still pulled out, massage it firmly between your hands for at least 10 seconds to help the
Suppository drugs are to cause bowel movement if inserted into the Anus between the first fifteen to sixty minute of inserting. If it doesn’t see a doctor. 

Side effects include
Irritation at the spot where you inserted it

It is advised that you Ask your doctor before you use a suppository if you:
• Have an irregular heartbeat
• Have had recent surgery on your rectum
• Are a man who's had prostate surgery recently
• Are a woman who’s had surgery or radiation treatment to your vaginal area

Source: Google